Polymyxin Antibiotics: From Laboratory Bench to Bedside (Advances in Experimental Medicine and Biology #1145) (Hardcover)

Polymyxin Antibiotics: From Laboratory Bench to Bedside (Advances in Experimental Medicine and Biology #1145) By Jian Li (Editor), Roger L. Nation (Editor), Keith S. Kaye (Editor) Cover Image
By Jian Li (Editor), Roger L. Nation (Editor), Keith S. Kaye (Editor)
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Description


Overview.- Multidrug resistant Gram-negative pathogens: the urgent need for 'old' polymyxins.- Discovery, antibacterial spectrum and chemistry.- Mechanisms of antibacterial activity.- Mechanisms of resistance.- Bioanalysis and stability of polymyxins.- In vitro pharmacodynamics and PK/PD in animals.- Antibacterial susceptibility breakpoints.- Labeling of parenteral products of colistin methanesulfonate.- Meta-analysis of polymyxin use in patients.- Clinical use of colistin.- Clinical use of polymyxin B.- Pharmacokinetics, pharmacodynamics, toxicodynamics and dosing recommendations.- Rational combinations with other antibiotics.- Toxicities in patients: management and mechanisms.- Antiendotoxin effect.- Discovery of novel polymyxin-like antibiotics.- Conclusion.


Product Details
ISBN: 9783030163716
ISBN-10: 3030163717
Publisher: Springer
Publication Date: August 12th, 2019
Pages: 366
Language: English
Series: Advances in Experimental Medicine and Biology